The circadian cycle: daily rhythms from behaviour to genes : Article : EMBO reports: "Increased incidence of radiation-induced cancers occur in Period 2 (Per2) mutant mice (Fu et al, 2002), and Clock mutants tend to develop obesity (Turek et al, 2005). Whether and how these pathologies are related to defective clock functions is not known, but lack of coordinated metabolic regulation might be part of the cause. When constructing a network of feedback loops in computer simulation, it is quite difficult to establish conditions that prevent chaotic behaviour (Roenneberg & Merrow, 2002)—these special conditions seem to have evolved in the form of the circadian clock. Among them is not only endogenous rhythmicity but also conditional responsiveness to environmental stimuli, which is necessary to prevent chaotic behaviour."
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